PDGFRA and central nervous system cancer: Consequently, DNA methylation may be extended in glioma cells to establish glioma CpG island methylator phenotype (G-CIMP) [129], and potentially leads to irreversible epigenetic alterations which commit glioma cells to oncogenesis, such as the silencing of tumour suppressive microRNA, miR-148a [130], as well as activation of oncogene, PDGFRA [131].