Furthermore, oncogenic STAT3 also confers resistance to autophagy by suppressing pro-autophagic pathways including Bcl-2/Beclin-1 and AMP-activated protein kinase ⍺ (AMPK⍺)/Unc-51-like kinase 1 (ULK1) signalling in GBM cells [66, 67]. The gene discussed is BECN1; the disease is glioblastoma.