Studies have therefore investigated the role of growth factor receptors involved in angiogenesis, such as the platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), and epidermal growth factor receptor (EGFR), contributing to the development of GBM as well as the therapeutic potential of these targets (Fig. 1A). This evidence concerns the gene PDGFRB and glioblastoma.