GRP and central nervous system cancer: In addition, nose-to-brain administration of three other types of nanosystems was attempted with promising results for the treatment of gliomas, using mixed micelles consisting of Tat-conjugated polymer micelles and stearoyl-modified bombesin, self-assembled nanoparticles of therapeutic RAGE-antagonist peptides and anti-miR21 antagomirs, and anti-oligonucleotide co-micelles against miR-21 [47–49].