Adiponectin is initially considered a guardian angel adipocytokine owing to its protective functions against various disease states associated with obesity, such as immune modulatory, insulin­sensitizing, antidiabetic, anti­obesogenic, anti­inflammatory, antiatherogenic, anti-fibrotic, cardio­ and neuroprotective properties [3, 4, 7]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.