In the PCOS group, Sutterella exhibited positive correlations with BMI (r2=0.31, FDR = 0.01), waist circumference (r2=0.29, FDR = 0.02), fasting glucose level (r2=0.46, FDR < 0.001), fasting insulin level (r2=0.24, FDR = 0.045), and zonulin (r2=0.25, FDR = 0.03) (Fig. 3a). The gene discussed is HP; the disease is polycystic ovary syndrome.