Additionally, PRKN and PINK1 mutations were discovered in young people with recessively inherited Parkinson's disease, and variants in these genes highlight deficits in mitochondrial function, mitophagy, and intracellular immunity.6, 7, 8 A pathogenic variant in VPS35 (c.1858G>A; Asp620Asn; NCBI accession number NM_018206.4) also leads to dominantly inherited parkinsonism. This evidence concerns the gene PINK1 and Parkinson disease.