The utilization of alternative TSSs or TESs imply the elongation of transcripts, such as RCC2, an oncogene associated with the proliferation (Wu et al. 2022), invasion (Chen et al. 2020), and epithelial-mesenchymal transition (Pang et al. 2017) of multiple cancers, or the truncation of transcripts, such as ESPN, a gene associated with cancer cell growth (Li et al. 2018). The gene discussed is ESPN; the disease is cancer.