On the other hand, if TDP-43 pathology promotes tauopathy, one would expect “pure LATE-NC” (lacking substantial ADNC) to have Tau-immunoreactive intraneuronal inclusions, colocalized with TDP-43 NCIs, in the dentate granule cells, well before predicted by classic Braak NFT staging (77). Here, MAPT is linked to tauopathy.