TARDBP and proteostasis deficiencies: This is because the distribution of pathologic findings in multiple autopsy cohorts are relatively consistent and instructive: the great majority of cases with HS in aging have LATE-NC; LATE-NC is approximately twice as common as HS-A; and brains with unilateral HS-A generally have bilateral TDP-43 proteinopathy (75, 78, 111–113, 125–129).