TAOK1 is capable of inhibiting lipid catabolic processes (mitochondrial β-oxidation and triacylglycerol secretion), augmenting lipid anabolic pathways (fatty acid influx and lipogenesis), and exacerbating oxidative/endoplasmic reticulum stress, thereby intensifying lipotoxicity in hepatocytes of NASH [23]. Here, TAOK1 is linked to metabolic dysfunction-associated steatohepatitis.