In order to further explore the potential underlying mechanism of GSG2 promoting EOC proliferation, we down-regulated the expression of GSG2 in Human ovarian cancer cells HO8910 and SKOV3 with Lentivirus-mediated RNAi, and the knockdown efficiency was verified by western blotting and real-time PCR (Fig. 1a, b). This evidence concerns the gene HASPIN and ovarian cancer.