In humans, epimutations and microdeletions that affect the IG-DMR or the MEG3 promoter are observed in two congenital imprinting disorders (IDs), Kagami-Ogata Syndrome (KOS14, OMIM 608149) and Temple Syndrome (TS14, OMIM 616222) (24–27). Here, MEG3 is linked to motor developmental delay due to 14q32.2 paternally expressed gene defect.