Particularly, we predict that in patients with Temple Syndrome (TS14) (29), and in some patients with the clinically overlapping Silver-Russell Syndrome (SRS) (24,84), their aberrant, biallelic MEG3 expression would lead to strongly reduced DLK1 in tissues in which this non-canonical Notch ligand is imprinted. The gene discussed is MEG3; the disease is motor developmental delay due to 14q32.2 paternally expressed gene defect.