illustrated that a single‐residue polymorphism in the transmembrane domain of FcγRIIB, known as FcγRIIB‐T232, which is linked to systemic lupus erythematosus (SLE) across global populations, resulted in a significant increase in the bending angle of the transmembrane helix. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.