In the univariate Cox regression (Table 2), positive expression of PD‐1 (HR = 7.561, p = 0.002), and PD‐L1 (HR = 6.189, p = 0.007), EBER+ (HR = 3.872, p = 0.026), IPI score >3 (HR = 3.829, p = 0.018), elevated LDH (HR = 10.356, p = 0.025), extra‐nodal sites >1 (HR = 4.096, p = 0.048), HIV‐1 RNA > 1 × 105 copies/mL (HR = 2.037, p = 0.046), B symptoms (HR = 4.901, p = 0.002), absence of cART (HR = 4.049, p = 0.049), and absence of chemotherapy (HR = 6.767, p < 0.001) were individual prognostic factors for the outcome in AR‐NHL patients. This evidence concerns the gene PDCD1 and non-Hodgkin lymphoma.