Immunofluorescence results of HL‐60 cells cocultured with HL‐60 cells from METTL5‐sh and METTL5‐NC groups showed MPO/H3 expression in METTL5‐NC group was higher than METTL5‐sh group, consistent with tumor tissue results (Figure 5Q–T). The gene discussed is METTL5; the disease is neoplasm.