The link between the GM and endothelium and PH was also suggested by the paper of Pinheiro et al. [53], reporting that a distinctive bacterial consortium exhibits the potential to ameliorate MASLD, type-2 diabetes, and obesity by reinstating endothelial function, improving insulin signaling, and retarding the progression of these conditions. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.