Interestingly, obeticholic acid has been shown to recover diminished FXR signaling in the ileum, enhance the mucus functionality, and stabilize the gut–vascular barrier in cirrhotic rats, supporting the idea that the nuclear receptor FXR plays a partial role in modulating mucus and the gut–vascular barrier in cirrhosis [55]. The gene discussed is NR1H4; the disease is Cirrhosis.