Also, TNBS-induced colitis significantly increased the MPO activity in the colon compared to that measured in the Control mice (p < 0.0001), while the AL0035 and MS groups were shown to have significantly decreased MPO accumulation in colonic tissue compared to the TNBS-vehicle-treated group (p < 0.01 and p < 0.001; Figure 3g). Here, MPO is linked to colitis.