HMGB1 and metabolic dysfunction-associated steatohepatitis: In a methionine and choline deficiency diet (MCDD)-caused nonalcoholic steatohepatitis (NASH) model, CGA increases the biogenetics of mitochondria and suppresses the generation of extracellular matrix triggered by HMGB1 in liver endothelial cells, thus attenuating liver fibrosis [179].