In conclusion, EPAS1/HIF-2α has close relationship with the occurrence and development of ccRCC, as the prognostic marker with the highest expression in renal carcinoma [55], and an important role in the ccRCC-related pathway, as shown in WikiPathways (https://www.wikipathways.org/pathways/, accessed on 5 January 2023) (Figure 7A). This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.