Interestingly, Kim et al. (2023) showed that, compared to White women, Black women with residual ER+ BC after neoadjuvant chemotherapy have worse distant recurrence-free survival, which can be due to a pro-metastatic TME and an increased density of “Tumor Microenvironment of Metastasis” (TMEM) doorways as portals for systemic cancer dissemination that contribute to racial disparities in BC [75]. This evidence concerns the gene ESR1 and breast cancer.