EGFR and neoplasm: These authors characterized the TMEM as microanatomical niches enriched for cancer stem cells (CECs) and composed of three-cell structures: a tumor cell that expresses the mammal-enabled (MENA) protein, an actin-regulatory protein involved in cell motility and adhesion [76], a tyrosine-protein kinase (TIE2)-expressing macrophage M2 and an endothelial cell, which can be together used by tumor cells as a portal to intravasate and disseminate into the bloodstream [77].