INS and premature menopause: Premature menopause, also named premature ovarian failure (POF) or premature ovarian insufficiency (POI), was reported by 1% of CAW, 1.4% of AAW, 1.4% of Hispanic women, 0.5% of Chinese women and 0.1% of Japanese women [99], with POI patients having a marginally higher insulin level [100].