Another pan-ALDH1 inhibitor, 637A, inhibits ALDH1A1 (IC50 = 246 nM), ALDH1A2 (230 nM), and ALDH1A3 (348 nM) induced calcium-dependent necroptosis in ovarian cancer cell line A2780 [72]. The gene discussed is ALDH1A1; the disease is ovarian carcinoma.