CXCR4 has an important role in the homing of progenitor cells to the bone marrow; thus, a blockade of CXCR4 is used when mobilization of cells to the periphery is desired (e.g., in some blood cancers like non-Hodgkin’s Lymphoma) [186]. This evidence concerns the gene CXCR4 and hematopoietic and lymphoid system neoplasm.