IFNG and colorectal cancer: Indeed, an Fc-optimized CD133 mAb, known as 293C3-SDIE, induces NK cell activation, degranulation, secretion of IFN-γ, and antibody-dependent cellular cytotoxicity, resulting in potent lysis of colorectal cancer cells Caco-2 and HCT-116, as well as B cell acute lymphoblastic leukemia cells, highlighting its potential in solid and hematologic malignancies [260,261].