On the contrary, Liutkeviciene et al. suggested that ApoE4/E2 genotype could be protective [36], Viturino et al. found no impact of ApoE2/E2 genotype on the increased risk of AMD [37], and Fernández-Vega et al. described a protective role of ApoE2 allele in wet AMD in a Spanish population [38]. The gene discussed is APOE; the disease is age-related macular degeneration.