Mice deficient in the C-C motif chemokine ligand 2 cytokines and C-X3-C motif chemokine receptor 1 (CCl2-/-/CX3CR1-/-) [133], in CCl2-/- alone or C-C chemokine receptor type 2 (CCR2-/-) receptors [134], show similar morphological, functional and structural characteristics of dry AMD. The gene discussed is CCL2; the disease is dry age related macular degeneration.