INS and prediabetes syndrome: Hence, this study aims to investigate changes in skeletal muscle strength using a high-fat, high-carbohydrate (HFHC) diet-induced prediabetic model, mainly focusing on the association between skeletal muscle grip strength and prediabetes-associated metabolic derangements such as hyperglycemia, elevated HbA1c concentrations, skeletal muscle fat infiltration, and insulin resistance.