Intriguingly, by inhibiting AMPA/kainate receptor desensitisation by exposing T1D donor pancreatic slices to cyclothiazide (a positive allosteric modulator of AMPA/kainate receptors approved by the FDA for edema treatment), the authors showed that alpha-cell [Ca2+]i and glucagon secretion during hypoglycaemia could be significantly improved [242]. This evidence concerns the gene GCG and type 1 diabetes mellitus.