Two significant pathways, hsa04080, Neuroactive ligand-receptor interaction, and hsa04950, Maturity onset diabetes of the young (MODoY; with transcription factors FOXA3, NKX6-1, MAFA, PAX6, PDX1), were identified for the genes expressed more highly in the high-CCNE1 tumours. The gene discussed is PAX6; the disease is neoplasm.