Monocytes attracted to the tumor site turn into tumor-associated macrophages (TAMs) that play the role of a two-sided coin: on one side, they kill tumor cells, and on the other side, they produce a number of angiogenic (VEGF-C, D, F) and lymphangiogenic growth factors, cytokines, and proteases involved in tumor biology and progression [69,70]. The gene discussed is VEGFC; the disease is neoplasm.