DDX53 and neoplasm: Although the authors revealed alterations in the cell surface glycosylation of immune cells, as the tumor-driven change in the sugar code (glyco-immunophenotype), and the authors identified 851 and 2164 differentially expressed proteins in the primary or secondary CT26-bearing organs, the authors could not address or identify the CT26-derived soluble factors that shaped the immunophenotype and altered the cell surface glycosylation of the immune cells.