Gal1 binding showed a significantly increased number of cells on CD3+ T cells in the case of spleen samples (13.92 ± 4.14 vs. 9.57 ± 2.13, p = 0.01); however, Gal3 binding was lower on CD3+ T cells of PBMC samples (21.91 ± 13.83 vs. 32.23 ± 5.89, p = 0.05) in mice with CRC vs. controls. Here, LGALS3 is linked to colorectal carcinoma.