An increased expression of theanine metabolite (Log2FC = 1.50) may also contribute to inflammation in the off-peak season, as it has been shown to have an anti-allergy effect by preventing the expression of allergic cytokines such as TNF-α, IL-1β, IL-6, and IL-8 via the inhibition of the NF-κB biopathway, occurring in allergy-mediating mast cells [23]. The gene discussed is IL1B; the disease is allergic disease.