Moreover, an anti-human SLAMF6/CD352 monoclonal antibody efficiently killed human CLL cells both in vitro (in combination with ibrutinib, it induced apoptosis in OSU-CLL cells) and in vivo (it reduced the growth of MEC-1 cells transplanted subcutaneously into [Rag x γc]−/− mice). Here, SLAMF6 is linked to B-cell chronic lymphocytic leukemia.