Two of these, cilia- and flagella-associated protein 298 (CFAP298) and general transcription factor II-I (GTF2I), were upregulated in OSA cell lines, while six proteins, namely mirror-image polydactyly 1 protein (MIPOL1), alpha-2-macroglobulin (A2M), phosphoglycerate mutase 1 (PGAM1), ubiquitin (UB2L6), ectodysplasin-A receptor-associated adapter protein (EDARADD), and leucine-rich-repeat-containing protein 72 (LRRC72), were downregulated in OSA cells compared to the control (Figure 1 and Figure 2). This evidence concerns the gene A2M and obstructive sleep apnea syndrome.