NETs were also identified as major drivers of heparin-induced thrombocytopenia/thrombosis (HIT), where IgG-heparin/platelet factor 4 complexes interact with FcγRIIa on neutrophils to trigger the formation of NET-rich thrombi, which could be blocked with PADI4 inhibitors experimentally [70]. This evidence concerns the gene PADI4 and Thrombocytopenia.