In addition, an intermediate state was represented by tumor 6, which was a recurrent tumor with a small proportion of spontaneous intracellular Ca2+ activity and less than 20% of non-responsive cells, and tumor 8, a silent GH/PRL/LH/FSH/TSH/ACTH adenoma with a proportion of mono responsive cells higher than 50% (Figure 2O and Figure 3). This evidence concerns the gene PLOD1 and adenoma.