To evaluate whether the tumor grade progression model (i.e., progression from LGG to HGG) was associated with aberrantly elevated levels of TMEM230 expression, open-access mRNA sequencing datasets were analyzed from patients with low-grade glioma (LGG), patients with high-grade glioma (HGG), and patients with glioblastoma multiforme (GBM). The gene discussed is TMEM230; the disease is central nervous system cancer.