Progress in glioma research would greatly benefit by understanding which genes, molecular pathways, and diverse cell types are regulated by TMEM230 and contribute to tissue infiltration, de novo formation of blood vessels, vascular mimicry, and microchannel formation in highly vascularized tumors such as glioblastoma multiforme and high-grade oligodendroglioma (ODG). Here, TMEM230 is linked to central nervous system cancer.