Similarly, significant increases in vascular Aβ in the αSMA+ area were seen in AD patients with severe CAA when contrasted with control patients (Z = 3.26, p = 0.0011) and AD patients with no CAA (Z = 2.58, p = 0.0099) or mild CAA (Z = 3.51, p = 0.0005). The gene discussed is ACTA1; the disease is Alzheimer disease.