Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is characterized by the accumulation of extracellular amyloid-β peptides (Aβ) within the cerebral parenchyma and vasculature, which is known as cerebral amyloid angiopathy (CAA), and intracellular neurofibrillary tangles consisting of hyperphosphorylated tau [1,2,3,4]. The gene discussed is MAPT; the disease is Alzheimer disease.