This is evident in the mean Aβ intensity within the CD31+ area (H(3) = 19.18, p = 0.0003; mean control = 9.21, mean AD no CAA = 8.83, mean AD mild CAA = 9.51, mean AD severe CAA = 30.63) and αSMA+ area (H(3) = 17.92, p = 0.0005; mean control = 10.15, mean AD no CAA = 12.59, mean AD mild CAA = 9.74, mean AD severe CAA = 90.25) (Figure 1E). This evidence concerns the gene PECAM1 and Alzheimer disease.