In vitro and in vivo experiments respectively in MiaPaCa-2, AsPC-1 human pancreatic cancer cell lines, and athymic mice xenograft models, show that inhibitors of ALOX5 (Rev-5901) and ALOX12 (baicalein) induce growth inhibition while activating apoptosis via the mitochondrial pathway [228]. This evidence concerns the gene ALOX12 and familial pancreatic carcinoma.