CDC42 and melanoma: Although relatively few Cdc42 oncogenic mutations have been reported in cancer [49,70], the overexpression of Cdc42 is observed in several types of cancers, such as breast [32,71,72,73], colorectal [74], esophageal [75], gastric [74], lung [76,77,78], melanoma [79], ovarian [80,81], pancreatic [82], and testicular cancers [83].