IL1A and neoplasm: The pattern of tumor development observed in immunodeficient mice was the opposite of that seen in WT mice (Figure 5 and Figure 6, Supplemental Figure S4), i.e., injection of IL-1α KO cells into immunodeficient mice resulted in a more rapid tumor growth and an extensive metastatic spread, compared to immunodeficient mice injected with 4T1/WT cells.