The results obtained indicated that the knockdown of BAX (Figure 7A,B) or PUMA (Figure 8A,B) was sufficient to reduce cell death and inhibit caspase activation induced by the RG7112 treatment, suggesting that BAX and PUMA were both required for the apoptotic death of glioma stem cells induced by the inhibition of MDM2. Here, MDM2 is linked to glioma.