Additionally, while we have addressed the ability of LMP2A to function in the context of the entire virus (Figure 6), since LMP1 and LMP2A activate similar pathways (PI3K, NF-kB, STAT3) [20,59,60,61] and have been shown to cooperate in promoting B cell lymphoma development [62], future studies should analyze if LMP1 and LMP2A enhance HIF-1α and ATP generation in an additive or synergistic manner. The gene discussed is HIF1A; the disease is B-cell non-Hodgkin lymphoma.