TGFB1 and cancer: Prune-1 is a multi-domain adaptor protein with an unfolded domain, allowing interactions with several binding partners and the modulation of different signaling cascades, including WNT and TGF-β signaling, and serves as nodal points in the regulation of many cellular activities [24,25] The WNT and TGF-β pathways are cell–cell signaling systems that control a plethora of processes, from embryonic development and cell proliferation, differentiation and migration, to tissue homeostasis, stem cell behavior, tissue regeneration, and cancers [26].