The results obtained by the mutational WES analysis of our Gr3 MB tumor, from which the primary cells were derived, show the presence of three pathogenic variants in the following genes: DAPK1 (NM_001288729; exon 11; c.C938A; p.S313X; stopgain); HSPH1 (NM_001286503; exon 2; c.G124T; p.G42X; stopgain); and LRP1B (NM_018557; exon 25; c.G4168T; p.G1390X; stopgain) (see Table 1). The gene discussed is LRP1B; the disease is neoplasm.