TP53 and neoplasm: In order to evaluate the predictive nature of p53 (positive) and Ki-67 (increased values > 14) of the disease-free interval (DFS) and long-term survival (OS-overall survival) we applied a univariate and multivariate analysis in the general group; the analysis included the following variables: age, presence or absence of menopause, family history of the patients, tumor size, tumor grading, Ki-67, lymphatic metastases (LN metastases), and p53.