ESR1 and neoplasm: In 2022, Xinru Wang et al. published an analysis including 220 patients regarding the association between the histological type of the tumor and lipid profile, concluding the association between the HDL-C and LDL-C values and the absence of positive hormonal status (PR, ER), thus the low values of HDL-C and LD-C being associated with the ER- and PR- subtypes [22,23].