Moreover, [11C]PiB accumulation has been seen in moyamoya disease (caused by stenosis/occlusion in the anterior cerebral circulation), probably because [11C]PiB, the mother of all the amyloid-PET probes, happens to be a high-affinity substrate for estrogen sulfotransferase SULT1E1, a very common brain enzyme related to inflammation [27] (Figure 4). Here, SULT1E1 is linked to Moyamoya disease.