TNF and chronic kidney disease: In the Chronic Renal Insufficiency Cohort (CRIC) study, baseline FKN/CX3CL1 levels were associated positively with all-cause mortality and cardiovascular risk factors, such as diabetes, hypertension, hyperlipidemia, higher body mass index (BMI), and higher plasma levels of the inflammatory markers (IL-6, TNF-α, and hsCRP) in adults with chronic kidney disease [87].