SOX2 and Alzheimer disease: Kaiso/ZBTB33 intervenes in the neuronal commitment of NSCs [48].ZBTB4 controls gene expression in different types of neurons (hippocampus, olfactory pathways, motor nuclei of the brainstem, and granular layer of the cerebellum) [49] and is associated with age-at-onset AD [50].ZBTB38 can repress transcription by binding to methylated DNA. It leads to early embryonic death via the suppression of the transcription factors Nanog and Sox2 [51].