The overexpression of KCNQ3 (Kv7.3) channels or local infusion of KCNQ opener ezogabine (also known as retigabine, selective for KCNQ2/3 subunits) in the VTA inhibited the increased firing rate of VTA dopamine neurons in susceptible mice and rescued depression-like behaviors [68]. This evidence concerns the gene KCNQ3 and depressive disorder.