Researchers from the Breast Cancer Now Toby Robins Research Centre revealed that cholesterol synthesis-related genes including MSMO1, EBP, LBR, and SQLE were upregulated in long-term estrogen-deprived BRCA cells; meanwhile, in silico analysis of two independent studies of primary ER+ BRCA patients treated with neoadjuvant aromatic inhibitors showed that the increased expression of these genes was significantly associated with a poor response to endocrine therapy and poor recurrence-free survival [101]. Here, ESR1 is linked to breast cancer.