Besides, HIF signaling may promote renal fibrosis via different mechanisms including epigenetic regulation, transcriptional regulation of fibrogenic genes, but also can crosstalk with other pro-fibrotic signaling pathways such as TGF-β, NF-κB, Notch, and PI3K/Akt pathways [86]. The gene discussed is NFKB1; the disease is renal fibrosis.