Our study is the first to demonstrate the effects of maternal hyperglycemic states with different severity levels classified as GDM-G1 and GDM-G2 on the profile of the colostrum appetite molecules, namely leptin, adiponectin, leptin–adiponectin ratio (LAR), resistin, ghrelin, and IGF-I, which are important factors for newborn and infant growth. Here, LEP is linked to gestational diabetes.