INS and type 2 diabetes mellitus: A monogenic Akita mouse strain (representative of T1DM because of a mutation in insulin gene that inhibits secretion) and a polygenic mouse strain, NONcNZO10/LtJ (representative of T2DM), both of which lack many of the extreme symptoms of leptin or leptin receptor gene mutation strains, were compared with STZ-induced and db/db mice for their potential for impaired wound healing [36].