Specifically, the observation that a high expression of EPHA2 in neuroblastoma [103], EPHB1 in glioma [79], EPHB6, ephrin-B2, and ephrin-B3 in neuroblastoma [101] correlates with a better prognosis is in line with a tumor-suppressive role of these EPHs. The gene discussed is EPHB6; the disease is central nervous system cancer.