Analogous findings have been reported for ephrins, with increased expression of ephrin-A3 and ephrin-A4 in ependymoma cell lines [95], of ephrin-B1 in medulloblastoma cell lines [67] and rhabdomyosarcoma tumor cells [120], and of ephrin-B2 in gliomas [80] and rhabdomyosarcoma tumor cells [120]. Here, EFNB1 is linked to central nervous system cancer.