Finally, studies using mouse models and medulloblastoma cells in culture to reveal the impact of EPH/ephrin signaling on the medulloblastoma invasive and metastatic capacity proposed ephrin-A5, which is involved in the phosphoinositide 3-kinase (PI3K)/Akt oncogenic pathway, and EPHB1, whose knockdown enhanced cellular radiosensitization, as promising therapeutic targets [70,71]. This evidence concerns the gene EPHA1 and medulloblastoma.