Namely, in medulloblastoma, ephrin-B1 has been shown to induce the phosphorylation of EPHB2 and to a lesser extent, EPHB4 [70]; EPHB4/ephrin-B2 signaling in glioma has been identified to promote angiogenesis [67,71], while Ephrin-A1-induced phosphorylation of EPHA2 has been reported to participate in osteosarcoma tumorigenesis [90]. This evidence concerns the gene EPHB4 and central nervous system cancer.