As it is described for the pediatric population, in adults, the EPH/ephrin signaling pathway has tumor-promoting (e.g., EPHB2 in breast tumors) or tumor-suppressing functions (e.g., EPHB6 in lung tumors) and is involved in a variety of tumors (e.g., hepatocellular carcinoma, colorectal cancer, melanoma, non-small cell lung carcinoma, and thymic tumors) [138,139,140,141,142,147]. Here, EPHB2 is linked to hepatocellular carcinoma.