EPHA2 shows overexpression predominantly in pediatric CNS tumors and malignancies arising from bone and soft tissues, namely glioma [73,74,75], medulloblastoma cell lines [67], craniopharyngioma [97], NF2-deficient meningioma [98], Ewing sarcoma [114], and osteosarcoma [113,114]. Here, EPHA2 is linked to osteosarcoma.