Towards this direction, EPHB4/ephrin-B2 signaling is explored as an antiangiogenic target, with anti-EPHB4 monoclonal antibodies successfully blocking EPHB4 signaling [89,90,91], while inhibition of EPHA2 and EPHB1-3 forward signaling in gliomas is associated with a dose-dependent reduction in cell invasion [92]. This evidence concerns the gene EPHB4 and central nervous system cancer.