Interestingly, as it is observed for the case of EPHB4, the same EPH can exert either a pro-tumorigenic (i.e., in neuroblastoma and rhabdomyosarcoma [106,120]) or anti-tumorigenic function (i.e., in ALL [131]) depending on the type of neoplasm it is expressed. The gene discussed is EPHB4; the disease is acute lymphoblastic leukemia.