SREBF1 and steatosis: Other studies confirmed that the combined agonistic action of GLP-1/GIP RAs [72,76] can reduce steatosis by downregulating the hepatic expression of lipogenic genes, including the transcription factor sterol regulatory element-binding protein 1 (Srebf1), 3-hydroxy-3-methylglutaryl-CoA reductase, cytochrome P450 family 27 subfamily A member 1 (Cyp27a1), and cytochrome P450 family 7 subfamily B member 1 (Cyp7b1) [76].