More recently, in a DIO-MASH mouse model mice, ALT-801, a dual GLP-1/GCG RA, was head-to-head compared to semaglutide monotherapy and elafibranor, a peroxisome proliferator-activated receptor, PPAR-α/δ, agonist, in a DIO mouse model of MASH [86]. Here, GLP1R is linked to metabolic dysfunction-associated steatohepatitis.