CYP2S1 and psoriasis: It has been demonstrated that in psoriasis-affected skin, the gene expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 is negatively correlated with DNA methylation, with a particular focus on intragenic hypomethylation of CYP2S1, highlighting the need for further investigation in the future [58] (Table 2).